Hurwitz J L, Hook B G, Flores B T, Marchlinski F E
Clinical Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia 19104.
J Am Coll Cardiol. 1993 Mar 15;21(4):895-900. doi: 10.1016/0735-1097(93)90344-z.
This study evaluates the ability of a third-generation cardioverter-defibrillator to abort energy delivery and the importance of electrogram storage in analyzing the aborted events.
In the Cadence Tiered Therapy Defibrillator, when a tachycardia satisfies detection criteria for cardioversion or defibrillation therapy, high voltage capacitors begin charging. The Cadence defibrillator continues monitoring the rhythm during charging and if the rate decreases to below the rate triggering therapy, charging is terminated. This event is registered as an aborted shock. The defibrillator also has the ability to store intracardiac electrogram recordings of the electrical events that precipitate device therapy or aborted shocks.
During a mean follow-up interval of 10 +/- 7 months, 55 aborted events were registered by the Cadence defibrillator in 18 of the 49 patients who received it. Thirty-two stored ventricular electrograms of events leading to aborted shocks were available for analysis in 15 patients.
Intracardiac electrogram recordings demonstrated the probable electrical events leading to these aborted shocks included nonsustained ventricular tachycardia (n = 10), nonsustained rapid polymorphic ventricular tachycardia/ventricular fibrillation (n = 2), atrial fibrillation (n = 5), supraventricular tachycardia (n = 2) and electrical noise (n = 13). Eleven patients had a therapeutic intervention initiated as a consequence of the diagnostic information provided by analysis of intracardiac electrogram recordings. Four of the 15 patients had no changes made. During a follow-up period of 9 +/- 5 months after therapy was altered, no patient had subsequent aborted shocks. Five patients have had seven appropriate shocks for sustained ventricular tachycardias.
The ability of Cadence defibrillator to continue tachycardia sensing during capacitor charging and to abort shock therapy for self-terminating events prevented unnecessary shocks in 18 (37%) of the 49 patients. Intracardiac electrogram recordings were critical for instituting appropriate therapy that may have prevented unnecessary device charging and inappropriate discharges.
本研究评估第三代心脏复律除颤器中止能量输送的能力以及心电图存储在分析中止事件中的重要性。
在Cadence分层治疗除颤器中,当心动过速满足心脏复律或除颤治疗的检测标准时,高压电容器开始充电。Cadence除颤器在充电过程中持续监测心律,如果心率降至触发治疗的心率以下,则充电终止。此事件被记录为中止电击。除颤器还能够存储引发设备治疗或中止电击的电事件的心内电图记录。
在平均随访间隔10±7个月期间,Cadence除颤器在49例接受该设备的患者中的18例中记录到55次中止事件。15例患者有32份导致中止电击事件的存储心室电图可供分析。
心内电图记录显示,导致这些中止电击的可能电事件包括非持续性室性心动过速(n = 10)、非持续性快速多形性室性心动过速/心室颤动(n = 2)、心房颤动(n = 5)、室上性心动过速(n = 2)和电噪声(n = 13)。11例患者因心内电图记录分析提供的诊断信息而开始进行治疗干预。15例患者中有4例未做任何改变。在治疗改变后的9±5个月随访期内,没有患者出现后续中止电击。5例患者因持续性室性心动过速接受了7次适当电击。
Cadence除颤器在电容器充电期间继续感知心动过速并为自终止事件中止电击治疗的能力,在49例患者中的18例(37%)中预防了不必要的电击。心内电图记录对于制定适当的治疗至关重要,这可能预防了不必要的设备充电和不适当的放电。