Lalonde R, Joyal C C, Botez M I
Hôtel-Dieu Hospital, Neurobiology Laboratory, Montreal, Quebec, Canada.
Pharmacol Biochem Behav. 1993 Mar;44(3):703-7. doi: 10.1016/0091-3057(93)90188-y.
Old rats had lower plasma concentrations of folates but not of vitamin B12 than young rats. Old rats injected with pharmacological doses of folic acid (5 mg/kg) or folinic acid (2.5 mg/kg) every 2 days for a 32-day period spontaneously alternated above chance levels at the 0-min retention interval whereas old rats injected with placebo did not. Rats injected with folinic acid that had plasma folate concentrations above the median for that group alternated at the 3-min retention interval whereas none of the other subgroups did. These results indicate that supplementation with folinic acid at pharmacological doses may decrease perseverative responding and improve spatial memory in old rats. However, neither vitamin group was improved in motor coordination, grip strength, or spatial learning in a water maze. There was no hyperactivity or loss of body weight following vitamin supplementation.
老年大鼠血浆中叶酸浓度低于年轻大鼠，但维生素B12浓度并非如此。在32天的时间里，每隔2天给老年大鼠注射药理剂量的叶酸（5毫克/千克）或亚叶酸（2.5毫克/千克），在0分钟的保持间隔时，它们自发交替的频率高于随机水平，而注射安慰剂的老年大鼠则没有。注射亚叶酸且血浆叶酸浓度高于该组中位数的大鼠在3分钟的保持间隔时出现交替，而其他亚组均未出现。这些结果表明，药理剂量的亚叶酸补充可能会减少老年大鼠的持续性反应并改善其空间记忆。然而，在水迷宫中，两个维生素组的运动协调性、握力或空间学习能力均未得到改善。补充维生素后既没有出现多动现象，也没有体重减轻的情况。
