乙酰唑胺对豚鼠内淋巴囊酸碱平衡的影响。

Effects of acetazolamide on acid-base balance in the endolymphatic sac of the guinea pig.

作者信息

Tsujikawa S, Yamashita T, Tomoda K, Iwai H, Kumazawa H, Cho H, Kumazawa T

机构信息

Department of Otorhinolaryngology, Kansai Medical University, Osaka, Japan.

出版信息

Acta Otolaryngol Suppl. 1993;500:50-3. doi: 10.3109/00016489309126179.

DOI:10.3109/00016489309126179

PMID:8452020

Abstract

The effects of acetazolamide, a carbonic anhydrase inhibitor, on acid-base parameters in the endolymphatic sac of the guinea pig were investigated using ion-selective microelectrodes. Bicarbonate concentration was reduced and pH shifted to being acidic immediately after administration of acetazolamide. Chloride concentration in the endolymphatic sac increased after carbonic anhydrase inhibition. These findings provide evidence of an active function of carbonic anhydrase in the endolymphatic sac and suggest that carbonic anhydrase activity is involved in the formation of endolymphatic sac fluid.

摘要

使用离子选择性微电极研究了碳酸酐酶抑制剂乙酰唑胺对豚鼠内淋巴囊酸碱参数的影响。给予乙酰唑胺后，碳酸氢盐浓度降低，pH值立即转变为酸性。碳酸酐酶抑制后，内淋巴囊中的氯离子浓度增加。这些发现为碳酸酐酶在内淋巴囊中的活性功能提供了证据，并表明碳酸酐酶活性参与了内淋巴囊液的形成。