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骨髓增殖性疾病：体内与体外血小板功能的矛盾现象。

Myeloproliferative disorders: a paradox of in-vivo and in-vitro platelet function.

作者信息

Boughton B J, Corbett W E, Ginsburg A D

出版信息

J Clin Pathol. 1977 Mar;30(3):228-34. doi: 10.1136/jcp.30.3.228.

DOI:10.1136/jcp.30.3.228
PMID:845271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476364/
Abstract

A patient with features of a myeloproliferative disorder developed an acute multisystems illness and died. In-vitro platelet aggregation was imparied, but necropsy revealed widespread platelet-rich thromboemboli and multiple organ infarctions. It is suggested that platelets are damaged during disseminated intravascular platelet aggregation (DIPA) and that disaggregation of platelet thrombi and recirculation of platelets give rise to their subsequent hypofunction when tested in vitro.

摘要

一名患有骨髓增殖性疾病的患者出现急性多系统疾病并死亡。体外血小板聚集受损，但尸检发现广泛存在富含血小板的血栓栓塞和多器官梗死。有人提出，在弥散性血管内血小板聚集（DIPA）过程中血小板受到损伤，并且血小板血栓的解聚和血小板的再循环导致它们在体外检测时随后出现功能减退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/41944c900f4b/jclinpath00161-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/2acfef937469/jclinpath00161-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/5713f0627cbc/jclinpath00161-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/9725d10ceb0d/jclinpath00161-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/bcd660695ac0/jclinpath00161-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/779ab2687e83/jclinpath00161-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/41944c900f4b/jclinpath00161-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/2acfef937469/jclinpath00161-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/5713f0627cbc/jclinpath00161-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/9725d10ceb0d/jclinpath00161-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/bcd660695ac0/jclinpath00161-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/779ab2687e83/jclinpath00161-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/476364/41944c900f4b/jclinpath00161-0038-b.jpg

相似文献

1
Myeloproliferative disorders: a paradox of in-vivo and in-vitro platelet function.骨髓增殖性疾病：体内与体外血小板功能的矛盾现象。
J Clin Pathol. 1977 Mar;30(3):228-34. doi: 10.1136/jcp.30.3.228.
2
[Blood platelet changes in myeloproliferative disorders].[骨髓增殖性疾病中的血小板变化]
Minerva Med. 1988 Oct;79(10):853-7.
3
Platelet function in myeloproliferative disorders: characterization and sequential studies show multiple platelet abnormalities, and change with time.骨髓增殖性疾病中的血小板功能：特征及系列研究显示存在多种血小板异常，并随时间变化。
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4
Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism?骨髓增殖性疾病中血小板活化因子诱导的血小板聚集缺陷：阿司匹林非依赖机制的缺乏？
Haemostasis. 1986;16(1):27-33. doi: 10.1159/000215266.
5
In vitro platelet aggregation defects in patients with myeloproliferative disorders and high platelet counts: are they laboratory artefacts?骨髓增殖性疾病及血小板计数高的患者的体外血小板聚集缺陷：它们是实验室假象吗？
Platelets. 2009 Mar;20(2):131-4. doi: 10.1080/09537100802691544.
6
Platelet unresponsiveness to collagen: involvement of glycoprotein Ia-IIa (alpha 2 beta 1 integrin) deficiency associated with a myeloproliferative disorder.
Thromb Haemost. 1995 Mar;73(3):521-8.
7
[Platelet function in chronic myeloproliferative syndromes associated with thrombocytosis].
Rev Med Chil. 1985 Jan;113(1):32-7.
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Abnormal aggregation and increased size of platelets in myeloproliferative disorders.骨髓增殖性疾病中血小板的异常聚集与体积增大。
Thromb Haemost. 1980 Jun 18;43(2):127-30.
9
[The platelet defect in myeloproliferative disorder (author's transl)].
Nouv Rev Fr Hematol (1978). 1976;16(3):443-6.
10
Abnormalities of platelet adenine nucleotides in patients with myeloproliferative disorders.骨髓增殖性疾病患者血小板腺嘌呤核苷酸异常。
Thromb Haemost. 1979 Jun 30;41(4):787-95.

引用本文的文献

1
Polycythemia and the heart. A review.红细胞增多症与心脏。综述。
Tex Heart Inst J. 1994;21(3):198-201.
2
The possible value of platelet aggregation studies in patients with increased platelet number.血小板数量增多患者血小板聚集研究的潜在价值。
Blut. 1981 Nov;43(5):279-85. doi: 10.1007/BF00320951.
3
Disorders of platelet function: mechanisms, diagnosis and management.血小板功能障碍：机制、诊断与管理

本文引用的文献

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Defective platelets in essential thrombocythemia.原发性血小板增多症中的血小板缺陷
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Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets.人类血小板的异质性。II. 提示存在年轻和衰老血小板的功能证据。
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[Megakaryocytic myelosis--clinical aspects, morphology and platelet function].[巨核细胞性骨髓增生症——临床症状、形态学及血小板功能]
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[Thrombocyte function in essential thrombocythemia and reactive thrombocytosis].[原发性血小板增多症和反应性血小板增多症中的血小板功能]
Klin Wochenschr. 1988 Mar 1;66(5):199-207. doi: 10.1007/BF01728197.
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Acquired platelet dysfunction with eosinophilia: review of seven adult cases.获得性血小板功能障碍伴嗜酸性粒细胞增多症：7例成人病例回顾
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Platelet satellitism and alpha granule proteins.血小板卫星现象与α颗粒蛋白
J Clin Pathol. 1991 Sep;44(9):788-9. doi: 10.1136/jcp.44.9.788.
4
Classification of thrombocytosis based on platelet function tests: correlation with hemorrhagic and thrombotic complications.基于血小板功能测试的血小板增多症分类：与出血和血栓形成并发症的相关性
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Abnormalities of platelet function in patients with polycythemia vera.
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The arterial complications of polycythaemia vera.真性红细胞增多症的动脉并发症。
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7
Effects of penicillin G on platelet aggregation, release, and adherence to collagen.青霉素G对血小板聚集、释放及黏附于胶原蛋白的影响。
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Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. I. The platelets: ultrastructure and peroxidase reaction.慢性骨髓增殖性疾病中的发育异常血小板和循环巨核细胞。I. 血小板：超微结构和过氧化物酶反应。
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The ultrastructure of megakaryocytes in polycythaemia vera and chronic granulocytic leukaemia.
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The effect of a partial release reaction on subsequent platelet function.部分释放反应对后续血小板功能的影响。
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