Fujita K, Miki N, Mojica M P, Takao S, Phuchareon J, Nishikawa S, Sudo T, Tokuhisa T
Department of Immunology, ICMR, Kobe University School of Medicine, Japan.
Int Immunol. 1993 Feb;5(2):227-30. doi: 10.1093/intimm/5.2.227.
c-fos and c-jun gene products form a heterodimeric complex (AP-1) that regulates target gene expression by binding to a specific DNA sequence motif. In order to study a role of AP-1 (Fos/Jun) in growth and differentiation of immature B lineage cells, we have established and mated two independent transgenic mice carrying the mouse c-fos gene or the viral v-jun gene fused to the H-2K promoter. IL-7 dependent bone marrow cell culture from doubly transgenic (H2-fos/jun) mice demonstrated severe delay of early B cell development. Proliferation of pre-B cells in the fresh bone marrow from H2-fos/jun mice to IL-7 stimulation was very low. These results suggest that the deregulated production of AP-1 perturbs IL-7 mediated proliferation and differentiation of immature B cells.
