Lau E M, Woo J, Leung P C, Swaminthan R
Department of Community and Family Medicine, Chinese University of Hong Kong.
Osteoporos Int. 1993 Mar;3(2):66-70. doi: 10.1007/BF01623375.
The purpose of the study was to compare the bone mineral density (BMD) at the hip and spine, the grip strength and the skinfold thickness in Chinese hip fracture patients and controls, and to document the relative risk of hip fracture associated with different levels of these risk factors. The study was conducted on 163 elderly patients with hip fracture (32 men and 131 women) and 317 controls (104 men and 213 women). BMD at the hip and spine was measured by dual-energy X-ray densitometry (Norland NR26). The mean grip strength was measured in both hands by a hand dynamometer; and bicep, tricep and iliac skinfold thicknesses were measured by a caliper (Holstain). Student's t-test was used to compare the mean bone densities, recalled body weight, grip strength and skinfold thickness; and multiple logistic regression was used to calculate the relative risk and 95% confidence intervals in quartiles of bone density, grip strength and skinfold thickness. In women, the mean BMD and anthropometric measurements were significantly lower in patients than controls. However, in men the mean recalled body weight and measured skinfold thickness were not significantly different between patients and controls. In both men and women the relative risk of hip fracture increased significantly with diminishing bone density at the spine, femoral neck and intertrochanteric area, but not at the Ward's triangle. In women the relative risk of hip fracture also increased significantly with a low recalled body weight, grip strength and skinfold thickness.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在比较中国髋部骨折患者与对照组在髋部和脊柱的骨密度(BMD)、握力及皮褶厚度,并记录与这些危险因素不同水平相关的髋部骨折相对风险。该研究纳入了163例老年髋部骨折患者(32例男性和131例女性)及317例对照者(104例男性和213例女性)。采用双能X线骨密度仪(Norland NR26)测量髋部和脊柱的骨密度。用握力计测量双手平均握力;用卡尺(Holstain)测量肱二头肌、肱三头肌及髂部皮褶厚度。采用学生t检验比较平均骨密度、回忆的体重、握力及皮褶厚度;采用多因素逻辑回归分析计算骨密度、握力及皮褶厚度四分位数的相对风险及95%置信区间。在女性中,患者的平均骨密度和人体测量指标显著低于对照组。然而,在男性中,患者与对照组之间回忆的平均体重和测量的皮褶厚度无显著差异。在男性和女性中,髋部骨折的相对风险均随脊柱、股骨颈和转子间区域骨密度的降低而显著增加,但在Ward三角区则不然。在女性中,髋部骨折的相对风险也随回忆的低体重、握力及皮褶厚度而显著增加。(摘要截选至250字)