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年轻患者的髋部骨折:这是早期骨质疏松症吗?

Hip fractures in young patients: is this early osteoporosis?

作者信息

Boden S D, Labropoulos P, Saunders R

机构信息

Department of Orthopaedic Surgery, George Washington University School of Medicine, Washington, DC 20037.

出版信息

Calcif Tissue Int. 1990 Feb;46(2):65-72. doi: 10.1007/BF02556089.

Abstract

Hip fracture in patients under age 50 is rare, and is often not attributable solely to the energy of injury. Our aim was to determine if trabecular bone mineral density (BMD) is abnormal in young patients with hip fractures. We reviewed all hip fractures treated at our institution between 1979 and 1986 and contacted 20 patients under the age of 50 at the time of injury, all of whom wished to be studied. The mean age at the time of injury was 39 (range 24-47). Subjects were questioned for osteoporosis risk factors, classified by level of energy producing their injury, and then underwent quantitative computed tomography (QCT) bone densitometry of trabecular bone in the lumbar spine. Bone mineral density by QCT was below the mean for age in 90% of the patients, and was greater than 1 SD below the mean in 75%. Mean percentage BMD decrease from age-matched controls was 34% (P less than 0.005) in women and 19% (P less than 0.005) in men. There was an inverse correlation in the degree of BMD decrease and the energy level of injury. There was a direct correlation of the severity of BMD decrease and the cumulative number of osteoporosis risk factors. This investigation has found that 1-7 years following hip fracture, otherwise presumedly healthy young patients demonstrate a statistically significant decrease in spinal BMD from age/sex-matched controls. These data do not determine if osteopenia is the cause or the result of injury, nor do we wish to infer that measurement of bone density at one site can predict future fractures at other sites.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

50岁以下患者的髋部骨折很少见,而且往往不能仅归因于损伤能量。我们的目的是确定年轻髋部骨折患者的小梁骨矿物质密度(BMD)是否异常。我们回顾了1979年至1986年在我们机构治疗的所有髋部骨折病例,并联系了20名受伤时年龄在50岁以下的患者,他们都希望接受研究。受伤时的平均年龄为39岁(范围24 - 47岁)。对受试者询问骨质疏松风险因素,根据造成其损伤的能量水平进行分类,然后对腰椎小梁骨进行定量计算机断层扫描(QCT)骨密度测定。通过QCT测得的骨矿物质密度在90%的患者中低于年龄均值,在75%的患者中低于均值1个标准差。与年龄匹配的对照组相比,女性BMD平均降低百分比为34%(P < 0.005),男性为19%(P < 0.005)。BMD降低程度与损伤能量水平呈负相关。BMD降低的严重程度与骨质疏松风险因素的累积数量呈正相关。这项研究发现,在髋部骨折后1 - 7年,原本看似健康的年轻患者与年龄/性别匹配的对照组相比,脊柱BMD有统计学上的显著降低。这些数据既不能确定骨质减少是损伤的原因还是结果,我们也不想推断在一个部位测量骨密度就能预测其他部位未来的骨折情况。(摘要截选至250字)

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