Overholt M A, Tschen J A, Font R L
Department of Pathology, Methodist Hospital, Baylor College of Medicine, Houston, Texas.
Cutis. 1993 Feb;51(2):95-8.
A fifty-three-year-old woman noted bilateral linear confluent papules involving the nasolabial folds following injection of bovine collagen (Zyderm). On light microscopic examination the dermis contained epithelioid granulomas centered around the degenerated bovine collagen. Electron microscopic examination demonstrated the degraded collagen fibers, which could be easily differentiated from the native collagen. The patient's clinical findings, management, and the pathogenetic mechanisms of this entity are reviewed.
一名53岁女性在注射牛胶原蛋白（Zyderm）后，双侧鼻唇沟出现线状融合性丘疹。光镜检查显示真皮内有围绕变性牛胶原蛋白的上皮样肉芽肿。电镜检查发现了降解的胶原纤维，其可轻易与天然胶原区分开来。本文对该病例的临床发现、处理及发病机制进行了综述。
