Eschbach J W, Korn D, Finch C A
J Lab Clin Med. 1977 Apr;89(4):823-8.
14C cyanate was employed as a red cell tag. Incubated cells were washed before reinjection to remove free cyanate. Neither early or late elution was observed, and the mean red cell life span of 10 normal subjects was 115+/-12 days. In nine uremic subjects the mean life span corrected for blood loss was 73 days with a mean red cell turnover of about 0.79 times basal. Survival curves in normal subjects were similar to those observed with DF32P and in uremic subjects to those with 51Cr corrected for elution. These observatios show the reliability of 14C cyanate as a nonelutable red cell tag.
14C 氰酸盐被用作红细胞标记物。孵育后的细胞在重新注射前进行洗涤以去除游离氰酸盐。未观察到早期或晚期洗脱现象，10名正常受试者的平均红细胞寿命为115±12天。9名尿毒症受试者经失血校正后的平均寿命为73天，平均红细胞周转率约为基础值的0.79倍。正常受试者的存活曲线与用DF32P观察到的相似，尿毒症受试者的存活曲线与经洗脱校正后的51Cr观察到的相似。这些观察结果表明14C氰酸盐作为一种不可洗脱的红细胞标记物具有可靠性。
