Grammer L C, Shaughnessy M A, Davis R A
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
J Occup Med. 1993 Mar;35(3):287-90.
We evaluated 96 workers employed at facilities that manufacture or use TMXDI (meta) aliphatic isocyanate and TMI (meta) unsaturated aliphatic isocyanate. We used immunoglobulin (Ig) and IgG serum antibody enzyme-linked immunosorbent assay (ELISA) studies and a questionnaire designed to identify symptoms compatible with work-related syndromes such as asthma and hypersensitivity pneumonitis. There were no workers with immunologically induced disease due to TMI isocyanate or TMXDI isocyanate nor were there any workers whose questionnaires suggested new onset of asthma. Approximately 40% of workers experienced some irritant symptoms, mostly upper respiratory or ocular. One worker had low level IgE antibody against TMXDI-HSA but had no work-related respiratory symptoms. Very low-level IgG against TMI-HSA or TMXDI-HSA was present in 7% of workers, all of whom were in the high-exposure category.
我们评估了96名在制造或使用TMXDI（间位）脂肪族异氰酸酯和TMI（间位）不饱和脂肪族异氰酸酯的工厂工作的工人。我们采用免疫球蛋白（Ig）和IgG血清抗体酶联免疫吸附测定（ELISA）研究，并设计了一份问卷，以识别与哮喘和过敏性肺炎等与工作相关综合征相符的症状。没有工人因TMI异氰酸酯或TMXDI异氰酸酯而患有免疫性疾病，也没有工人的问卷显示有哮喘新发情况。约40%的工人出现了一些刺激性症状，主要是上呼吸道或眼部症状。一名工人针对TMXDI-HSA的IgE抗体水平较低，但没有与工作相关的呼吸道症状。7%的工人存在针对TMI-HSA或TMXDI-HSA的极低水平IgG，所有这些工人都属于高暴露类别。
