Reisfeld B, Blackband S, Calhoun V, Grossman S, Eller S, Leong K
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Magn Reson Imaging. 1993;11(2):247-52. doi: 10.1016/0730-725x(93)90029-d.
A method has been developed to track controlled drug release and transport in the brain. This method entails the use of a polymeric implant to release, over time, a paramagnetically labelled compound into the brain. Magnetic resonance imaging is used to determine the evolving concentration distribution. This method is well suited to other types of intracranial drug delivery systems as well as to track transport in other organs of the body.
已开发出一种方法来追踪大脑中受控药物的释放和运输。该方法需要使用聚合物植入物，随着时间的推移，将顺磁性标记的化合物释放到大脑中。利用磁共振成像来确定不断变化的浓度分布。这种方法也非常适用于其他类型的颅内给药系统，以及追踪身体其他器官中的运输情况。
