Hunziker T, Schmidli J
Dermatologische Klinik, Universität Bern.
Ther Umsch. 1993 Feb;50(2):110-3.
Whereas psoriasis is well defined as a clinical entity for more than a century, the pathogenesis of psoriasis is still open to debate, despite demonstration of multiple abnormalities in cell-kinetics, histomorphology and biochemistry. Recent research indicates altered immune function in psoriatic skin, which may explain some of the phenomena typical for this disease. The role of immunological pathomechanisms in psoriasis is further substantiated by the well-known success of immunosuppressive treatments. However, as long as putative auto-antigens, which are presumed to perpetuate the pathological immune reactions, are not identified, psoriasis cannot be classified as an autoimmune disease.
尽管银屑病作为一种临床实体已被明确界定了一个多世纪，但尽管在细胞动力学、组织形态学和生物化学方面已证实存在多种异常，其发病机制仍存在争议。最近的研究表明银屑病皮肤中的免疫功能发生了改变，这可能解释了该疾病的一些典型现象。免疫抑制治疗的显著成功进一步证实了免疫病理机制在银屑病中的作用。然而，只要尚未确定那些被认为会使病理性免疫反应持续存在的假定自身抗原，银屑病就不能被归类为自身免疫性疾病。
