Egawa H, Shaked A, Konishi Y, McDiarmid S V, Vargas J, Shimahara Y, Colonna J, Mori K, Yamamoto N, Ozawa K
Department of Surgery, University of California, Los Angeles.
Transplantation. 1993 Mar;55(3):522-6. doi: 10.1097/00007890-199303000-00012.
Arterial ketone body ratio (AKBR) was measured serially in 49 pediatric orthotopic liver transplantations. The AKBR pattern correlated with hepatic synthetic function, as well as with short-term graft and patient survival. A rapid recovery pattern of AKBR to above 1.0 within 40 hr after reperfusion was associated with 94% graft and patient survival. Pediatric liver grafts were found to have better tolerance to low energy levels when compared with previously published data for adult OLT. The salvage rate of pediatric grafts exhibiting a slow recovery pattern (AKBR 0.7-1.0) was 71%. No recovery pattern (AKBR < 0.7) was seen in all 6 cases of primary nonfunction, and in 3 of 4 cases of early hepatic artery thrombosis (HAT). All these grafts were lost; however, 56% of the children in this group survived retransplantation. Unlike the PNF grafts, the no recovery pattern after HAT was characterized by gradual improvement of the synthetic function, despite the low energy state.
对49例小儿原位肝移植患者连续测量动脉酮体比率（AKBR）。AKBR模式与肝脏合成功能以及短期移植物和患者生存率相关。再灌注后40小时内AKBR迅速恢复至1.0以上的模式与94%的移植物和患者生存率相关。与先前发表的成人原位肝移植数据相比，发现小儿肝移植物对低能量水平具有更好的耐受性。表现为恢复缓慢模式（AKBR 0.7 - 1.0）的小儿移植物的挽救率为71%。在所有6例原发性无功能病例以及4例早期肝动脉血栓形成（HAT）病例中的3例中，未见恢复模式（AKBR < 0.7）。所有这些移植物均丢失；然而，该组中56%的儿童在再次移植后存活。与原发性无功能移植物不同，HAT后无恢复模式的特征是尽管能量状态较低，但合成功能逐渐改善。
