Takada Y, Ozaki N, Ringe B, Mori K, Gubernatis G, Oellerich M, Yamaguchi T, Kiuchi T, Shimahara Y, Yamaoka Y
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Transpl Int. 1992 Mar;5(1):23-6. doi: 10.1007/BF00337185.
To evaluate the ability of arterial ketone body ratio (AKBR; acetoacetate/3-hydroxybutyrate) to predict graft prognosis after liver transplantation, the diagnostic value as a predictive index was compared between AKBR and conventional liver function tests using receiver operating characteristic (ROC) analysis. The ROC curves were determined for AKBR, GOT, GPT, total bilirubin, serum lactate level, and prothrombin time, all of which were measured on the 1st and 2nd postoperative days in 88 cases of liver transplantation. Comparisons of the areas under the ROC curves between AKBR and other tests revealed the significant superiority of AKBR to other tests in predicting graft death within 1 month after transplantation. The present study suggests that AKBR can be used as an accurate index to predict graft prognosis after liver transplantation.
为评估动脉血酮体比率（AKBR；乙酰乙酸/3-羟基丁酸）预测肝移植后移植物预后的能力，采用受试者工作特征（ROC）分析比较了AKBR与传统肝功能检查作为预测指标的诊断价值。测定了88例肝移植患者术后第1天和第2天的AKBR、谷草转氨酶（GOT）、谷丙转氨酶（GPT）、总胆红素、血清乳酸水平和凝血酶原时间的ROC曲线。ROC曲线下面积的比较显示，在预测移植后1个月内移植物死亡方面，AKBR显著优于其他检查。本研究提示，AKBR可作为预测肝移植后移植物预后的准确指标。
