Raederstorff D, Moser U
F. Hoffmann-La Roche Ltd., Department of Vitamin and Nutrition Research, Basel, Switzerland.
Lipids. 1992 Dec;27(12):1018-23. doi: 10.1007/BF02535582.
The aim of this study was to evaluate the effect of different doses and sources of dietary gamma-linolenic acid (GLA) on the tissue phospholipid fatty acid composition. Rats fed four different levels of GLA (2.3, 4.6, 6.4 and 16.2 g of GLA/kg diet) in the form of either borage oil or evening primrose oil during 6 wk were compared with animals fed corn oil. The levels of dihomo-gamma-linolenic acid (DHLA) and GLA showed a significant dose-related increase in liver, erythrocyte and aorta phospholipids. Moreover, the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietary GLA. There was no significant difference in tissue GLA and DHLA levels within groups given equal amounts of dietary GLA either as borage oil or evening primrose oil. The amount of dietary GLA administered did not significantly influence prostaglandin E2 production in stimulated aortic rings and thromboxane B2 levels in serum; however, an increase in prostaglandin E1 derived from DHLA was observed in the supernatants of stimulated aorta.
本研究的目的是评估不同剂量和来源的膳食γ-亚麻酸（GLA）对组织磷脂脂肪酸组成的影响。将在6周内以琉璃苣油或月见草油形式喂食四种不同水平GLA（2.3、4.6、6.4和16.2 g GLA/kg日粮）的大鼠与喂食玉米油的动物进行比较。二高-γ-亚麻酸（DHLA）和GLA的水平在肝脏、红细胞和主动脉磷脂中呈现出显著的剂量相关增加。此外，随着膳食GLA摄入量的增加，组织中花生四烯酸/DHLA比值降低。给予等量膳食GLA的组内，无论是琉璃苣油还是月见草油，组织GLA和DHLA水平均无显著差异。给予的膳食GLA量对刺激的主动脉环中前列腺素E2的产生和血清中血栓素B2水平没有显著影响；然而，在刺激的主动脉上清液中观察到源自DHLA的前列腺素E1增加。
