Sørensen J D, Olsen S F, Pedersen A K, Boris J, Secher N J, FitzGerald G A
Department of Obstetrics and Gynecology, University of Aarhus, Denmark.
Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):915-22. doi: 10.1016/s0002-9378(12)90845-5.
Disturbance in thromboxane and prostacyclin biosynthesis has been observed in preeclampsia. We studied whether fish oil supplementation in late pregnancy interferes with maternal and fetal production of thromboxane A2 and prostacyclin I2.
Forty-seven women in the thirtieth week of pregnancy were randomly assigned in a ratio of 2:1:1 to receive fish oil (2.7 gm of n-3 fatty acid per day [Pikasol], or either olive oil or no oil supplementation as controls. Metabolites of thromboxane A2 and A3 and of prostacyclin I2 and I3 were quantified by mass spectrometry methods in serum and urine, respectively. Maternal serum and urine were sampled at baseline, in the thirty-third and thirty-seventh weeks of pregnancy. Fetal serum was sampled at delivery.
At the thirty-seventh week the mean concentrations of the eicosapentaenoic-derived metabolites, thromboxane B3 and prostacyclin I3, was twofold to threefold higher (p < 0.001) in the group receiving fish oil compared with combined control groups. There were no significant effects of fish oil on the prostacyclin I2 metabolite, although there was a trend toward a reduction in thromboxane B2 in this group. In umbilical cord blood the mean concentration of thromboxane B2 was lowest in the group receiving fish oil (p = 0.03).
Fish oil was metabolized to the eicosapentaenoic acid-derived eicosanoids thromboxane A3 and prostacyclin I3 in pregnant women. Correspondingly, analog products of arachidonic acid tended to be depressed. It remains to be established whether these biochemical effects will prove beneficial in the prevention or treatment of preeclampsia and intrauterine growth retardation.
子痫前期患者已观察到血栓素和前列环素生物合成紊乱。我们研究了妊娠晚期补充鱼油是否会干扰母体和胎儿血栓素A2和前列环素I2的生成。
47名妊娠30周的妇女按2:1:1的比例随机分组，分别接受鱼油（每天2.7克n-3脂肪酸[Pikasol]）、橄榄油或不补充油作为对照。分别采用质谱法对血清和尿液中血栓素A2和A3以及前列环素I2和I3的代谢产物进行定量分析。在基线、妊娠第33周和第37周采集母体血清和尿液样本。分娩时采集胎儿血清样本。
在妊娠第37周时，与联合对照组相比，接受鱼油组中二十碳五烯酸衍生的代谢产物血栓素B3和前列环素I3的平均浓度高出两到三倍（p < 0.001）。鱼油对前列环素I2代谢产物无显著影响，尽管该组血栓素B2有降低趋势。在脐带血中，接受鱼油组的血栓素B2平均浓度最低（p = 0.03）。
孕妇体内鱼油代谢为二十碳五烯酸衍生的类花生酸血栓素A3和前列环素I3。相应地，花生四烯酸的类似产物趋于减少。这些生化效应在预防或治疗子痫前期和胎儿生长受限方面是否有益仍有待确定。
