Sugawa-Katayama Y, Morita N
J Nutr. 1975 Nov;105(11):1377-83. doi: 10.1093/jn/105.11.1377.
The effect of a high fructose diet on lipogenesis was studied in rats. Male and female rats were divided into three groups and were fed a high carbohydrate diet ad libitum for 4 days: group 1 was fed a high cornstarch diet, group 2 was fed a high fructose diet without starvation, and group 3 was fed a high fructose diet after 2 days of starvation. The activities of lipogenic enzymes, i.e., glucose-6-phosphate dehydrogenase and malic enzyme were assayed in liver, adipose tissue, and small intestine. The lipid content of liver was also determined. On day 4, the lipid content of group 1 was about 45 mg, that of group 2 was about 70 mg, and that of group 3 was about 115 mg (female) and 145 mg (male) per gram of wet weight. Groups 2 and 3 showed significantly higher activity of hepatic malic enzyme than group 1. The activity of intestinal malic enzyme was highest in group 1 and not significantly different between groups 2 and 3. The malic enzyme activity in adipose tissue of females of group 3 was higher than that in either sex of the other groups.
在大鼠中研究了高果糖饮食对脂肪生成的影响。将雄性和雌性大鼠分为三组，随意喂食高碳水化合物饮食4天：第1组喂食高玉米淀粉饮食，第2组喂食无饥饿状态的高果糖饮食，第3组在饥饿2天后喂食高果糖饮食。测定了肝脏、脂肪组织和小肠中脂肪生成酶（即葡萄糖-6-磷酸脱氢酶和苹果酸酶）的活性。还测定了肝脏的脂质含量。在第4天，每克湿重中，第1组的脂质含量约为45毫克，第2组约为70毫克，第3组雌性约为115毫克，雄性约为145毫克。第2组和第3组肝脏苹果酸酶的活性显著高于第1组。第1组小肠苹果酸酶的活性最高，第2组和第3组之间无显著差异。第3组雌性脂肪组织中的苹果酸酶活性高于其他组的任何性别。
