Hiele M, Ghoos Y, Rutgeerts P, Vantrappen G
Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
Br J Nutr. 1993 Jan;69(1):169-76. doi: 10.1079/bjn19930019.
The metabolism of erythritol was assessed in six normal volunteers by measuring the amount of 13CO2 excretion and H2 excretion in breath, and erythritol in urine after intake of 25 g 13C-labelled erythritol. The results were compared with the same variables obtained after intake of 25 g 13C-labelled glucose and 13C-labelled lactitol. In addition, the H2 production by faecal flora supplemented with small amounts of erythritol, glucose and lactitol was measured in vitro, as an index of bacterial metabolism of non-absorbed substrate. In contrast to the results obtained after intake of glucose and lactitol, no increase in breath 13CO2 and H2 was observed after intake of erythritol, and erythritol was nearly completely recovered in urine. The in vitro experiments showed that no H2 was formed by faecal flora from erythritol as compared with glucose and lactitol. It is concluded that erythritol is a substrate that is readily absorbed, and undergoes no metabolism by the host. If part of it escapes absorption, it is not metabolized by faecal flora.
通过测量25克13C标记的赤藓糖醇摄入后呼出气体中13CO2和H2的排出量以及尿液中赤藓糖醇的含量，对6名正常志愿者体内赤藓糖醇的代谢情况进行了评估。将结果与摄入25克13C标记的葡萄糖和13C标记的乳糖醇后获得的相同变量进行比较。此外，作为未吸收底物细菌代谢指标，在体外测量了补充少量赤藓糖醇、葡萄糖和乳糖醇的粪便菌群产生H2的情况。与摄入葡萄糖和乳糖醇后的结果相反，摄入赤藓糖醇后未观察到呼出气体中13CO2和H2增加，且尿液中几乎完全回收了赤藓糖醇。体外实验表明，与葡萄糖和乳糖醇相比，粪便菌群未利用赤藓糖醇产生H2。得出的结论是，赤藓糖醇是一种易于吸收的底物，宿主不会对其进行代谢。如果有部分赤藓糖醇未被吸收，它也不会被粪便菌群代谢。
