Grimble G K, Patil D H, Silk D B
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.
Gut. 1988 Dec;29(12):1666-71. doi: 10.1136/gut.29.12.1666.
The fate of orally ingested lactitol, a non-absorbed sugar, was measured in six healthy human subjects by following the three routes of disposal of universally 14C-labelled sugar. Lactitol was given as a 20 g daily dose to six healthy volunteers for 14 days and on the seventh day, 10 muCi of L-[U-14C]-lactitol was given with the unlabelled sugar and excretion of the 14C in breath, urine and faeces was followed. The peak of 14CO2 excretion occurred at six hours and total 14CO2 accounted for 62.9 (5.0)% of isotope given, whilst 6.5 (3.6)% and 2.0 (0.3)% of the label were recovered from faeces and urine respectively. These data suggest that lactitol is extensively metabolised in the human colon and that a significant proportion of the bacterial metabolites are available for colonic absorption. Calculation revealed that 54.5% of the theoretical energy content of this compound was utilised by the subjects. It is suggested that this sugar, and other soluble 'non-absorbed' sugars (lactulose, sorbitol, mannitol), may undergo a similar pattern of colonic metabolism and can be considered as reduced calorie compounds.
通过追踪普遍标记有(^{14}C)的糖的三种处置途径，在六名健康人体受试者中测定了口服摄入的非吸收性糖乳糖醇的代谢情况。给六名健康志愿者每天服用(20)克乳糖醇，持续(14)天，在第(7)天，将(10)微居里的(L-[U-^{14}C])-乳糖醇与未标记的糖一起给予，并追踪呼出气体、尿液和粪便中(^{14}C)的排泄情况。(^{14}CO_2)排泄峰值出现在(6)小时，呼出的(^{14}CO_2)总量占给予同位素的(62.9(5.0)%)，而分别从粪便和尿液中回收了(6.5(3.6)%)和(2.0(0.3)%)的标记物。这些数据表明，乳糖醇在人体结肠中被广泛代谢，并且很大一部分细菌代谢产物可被结肠吸收。计算表明，受试者利用了该化合物理论能量含量的(54.5%)。有人提出，这种糖以及其他可溶性“非吸收性”糖（乳果糖、山梨醇、甘露醇）可能会经历类似的结肠代谢模式，并且可以被视为低热量化合物。
