Min B, Kim I, Kim H
Department of Biomedical Engineering, College of Medicine, Seoul National University, Korea.
Int J Artif Organs. 1993 Jan;16(1):45-50.
A new electromechanical moving-actuator type total artificial heart (TAH) has been developed to solve the imbalance problem without an extra compliance chamber. A different stroke volume was achieved by the large left sac size and the asymmetry of the actuator motion referred to the center position. The left ventricle consists of a double sac with the outer sac attached to the actuator providing active diastolic filling, while the double sac of the right ventricle being free from the actuator, and having sufficient suction produced due to the rigid pump housing. The stroke volume difference between the left and right sac is compensated through the air in the interventricular space of the variable volume (VV) space. Computer simulation based on the geometrical relationships between the blood sacs and the actuator was performed to simulate the physical mechanisms of the moving-actuator type TAH. Results were then compared with the measured pressure changes in various chambers of the pump and the stroke volume differences in mock circulation test. In two acute calf experiments, the balanced left and right atrial pressures were achieved in the moving-actuator type TAH without an extra compliance chamber.
为解决无额外顺应腔的失衡问题，已研发出一种新型机电驱动型全人工心脏（TAH）。通过较大的左腔尺寸和相对于中心位置的驱动运动不对称性实现了不同的 stroke volume（搏出量）。左心室由双腔组成，外腔连接到驱动装置以提供主动舒张期充盈，而右心室的双腔则与驱动装置分离，并因刚性泵壳产生足够的吸力。左右腔之间的搏出量差异通过可变容积（VV）空间的心室内空间中的空气来补偿。基于血腔与驱动装置之间的几何关系进行了计算机模拟，以模拟驱动型TAH的物理机制。然后将结果与泵各腔室中测得压力变化以及模拟循环测试中的搏出量差异进行比较。在两项急性小牛实验中，在无额外顺应腔的驱动型TAH中实现了左右心房压力平衡。
