重组人转化生长因子-β1在大鼠和兔子中的病理学研究
Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits.
作者信息
Terrell T G, Working P K, Chow C P, Green J D
机构信息
Department of Safety Evaluation, Genentech, Inc., South San Francisco, California 94080.
出版信息
Int Rev Exp Pathol. 1993;34 Pt B:43-67. doi: 10.1016/b978-0-12-364935-5.50009-2.
The systemic administration of high doses of rHuTGF-beta 1 to rats produced a spectrum of lesions in multiple target tissues, including liver, bone, kidney, heart, thymus, pancreas, stomach, cecum, at the injection vein, and in skeletal muscle at the site of anesthetic injection. The majority of these lesions can be attributed to known biological activities of TGF-beta 1. High-dose dermal application resulted in local effects at the wound sites without systemic toxicity.
给大鼠全身注射高剂量的重组人转化生长因子β1（rHuTGF-β1）会在多个靶组织中产生一系列病变，包括肝脏、骨骼、肾脏、心脏、胸腺、胰腺、胃、盲肠、注射静脉处以及麻醉注射部位的骨骼肌。这些病变中的大多数可归因于TGF-β1已知的生物学活性。高剂量皮肤给药会在伤口部位产生局部效应，而无全身毒性。
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