Morgan P R, Shirlaw P J, Johnson N W, Leigh I M, Lane E B
J Oral Pathol. 1987 Apr;16(4):212-22. doi: 10.1111/j.1600-0714.1987.tb02068.x.
Recent progress in understanding the biology of keratins together with the development of monoclonal antibodies to individual keratin proteins provide the foundation for studying keratin expression in normal and pathological oral epithelia. Areas of oral pathology in which the examination of epithelial keratin profiles may yield information of potential diagnostic value are discussed. Examples of altered keratin expression in epithelial dysplasia, oral cancer and odontogenic cysts and tumours are presented. Immunocytochemical demonstration of individual keratins can clarify the composition of complex epithelia and may help to establish epithelial lineage or indicate progression changes in tumours. Some problems in the application and interpretation of keratin immunocytochemistry are also considered.
近年来在角蛋白生物学认识方面取得的进展，以及针对单个角蛋白蛋白的单克隆抗体的研发，为研究正常和病理状态下口腔上皮中的角蛋白表达奠定了基础。本文讨论了口腔病理学领域中，检查上皮角蛋白谱可能产生具有潜在诊断价值信息的情况。文中列举了上皮发育异常、口腔癌以及牙源性囊肿和肿瘤中角蛋白表达改变的实例。对单个角蛋白进行免疫细胞化学鉴定能够阐明复杂上皮的组成，有助于确定上皮谱系或提示肿瘤的进展变化。同时也考虑了角蛋白免疫细胞化学应用和解读中的一些问题。
