Yokozawa T, Fujitsuka N, Oura H, Akao T, Kobashi K, Ienaga K, Nakamura K, Hattori M
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Nephron. 1993;63(4):452-7. doi: 10.1159/000187251.
Methylguanidine (MG)-synthesizing enzyme was purified from rat kidney lysosomes and peroxisomes. The enzyme was a flavoprotein with a molecular weight of about 37,000 and oxidized creatol to produce MG. The present results suggest that the reaction mechanism of this enzyme is different from that of L-gulono-gamma-lactone oxidase (EC 1.1.3.8) isolated from rat liver microsomes.
从大鼠肾脏溶酶体和过氧化物酶体中纯化出了甲基胍（MG）合成酶。该酶是一种分子量约为37000的黄素蛋白，可氧化肌醇生成MG。目前的结果表明，这种酶的反应机制与从大鼠肝脏微粒体中分离出的L-古洛糖酸γ-内酯氧化酶（EC 1.1.3.8）不同。
