Castro L C, Allen R, Ogunyemi D, Roll K, Platt L D
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
Obstet Gynecol. 1993 Apr;81(4):551-5.
To determine the acute effects of smoking during pregnancy on selected characteristics of the flow velocity waveform of the uterine artery.
We studied 19 chronic smokers at a mean (+/- standard error) gestational age of 28 +/- 1 weeks. After informed consent was given, the uterine artery was located using ultrasound imaging with color flow mapping. The characteristic waveform was imaged by pulsed Doppler ultrasonography. Maternal heart rate and blood pressure and the systolic-diastolic ratio (S/D) and resistance index of the uterine artery were measured before (-10 and -1 minutes), during (+5 and +10 minutes), and after (+20 and +30 minutes) smoking two standard cigarettes in succession.
Maternal heart rate increased 27%, systolic blood pressure increased 8%, and diastolic blood pressure increased 19% with smoking (P < .001). The uterine artery S/D and resistance index decreased from 2.33 to 2.02 and from 0.55 to 0.49, respectively (P < .001).
The acute effects of smoking on maternal systemic hemodynamics probably influence the flow velocity waveform of the uterine artery and preclude any definitive interpretation of acute changes in downstream resistance.
确定孕期吸烟对子宫动脉血流速度波形特定特征的急性影响。
我们研究了19名慢性吸烟者，其平均（±标准误差）孕周为28±1周。在获得知情同意后，使用彩色血流图超声成像定位子宫动脉。通过脉冲多普勒超声成像获取特征波形。在连续吸两支标准香烟之前（-10分钟和-1分钟）、期间（+5分钟和+10分钟）以及之后（+20分钟和+30分钟）测量孕妇心率、血压以及子宫动脉的收缩期与舒张期比值（S/D）和阻力指数。
吸烟时孕妇心率增加27%，收缩压增加8%，舒张压增加19%（P<.001）。子宫动脉S/D和阻力指数分别从2.33降至2.02以及从0.55降至0.49（P<.001）。
吸烟对孕妇全身血流动力学的急性影响可能会影响子宫动脉的血流速度波形，并且妨碍对下游阻力急性变化的任何明确解释。
