Ashwood E R, Palmer S E, Taylor J S, Pingree S S
Department of Pathology, University of Utah School of Medicine, Salt Lake City.
Obstet Gynecol. 1993 Apr;81(4):619-24.
To evaluate amniotic fluid lamellar body counting as a fetal lung maturity test. Lamellar body particles can be rapidly counted using the platelet channel of most blood cell analyzers.
We conducted a 3-year prospective clinical outcome study. During the interval under study, outcomes of 247 neonates were used to evaluate the test; 28 neonates developed respiratory distress syndrome (RDS). Lecithin-sphingomyelin ratio (L/S) was available for 187 cases.
All cases of RDS had lamellar body counts of 55,000/microL or less and L/S of 2.2 or less; 59% of cases with no RDS had counts greater than 55,000/microL and 70% of normal cases had L/S higher than 2.2.
Use of lamellar body counts is justified as a rapid screening test to predict fetal lung maturity. Immature results should be followed by a more specific test such as L/S.
评估羊水板层小体计数作为胎儿肺成熟度检测的方法。使用大多数血细胞分析仪的血小板通道可快速计数板层小体颗粒。
我们进行了一项为期3年的前瞻性临床结局研究。在研究期间，用247例新生儿的结局评估该检测方法；其中28例新生儿发生呼吸窘迫综合征（RDS）。187例可获得卵磷脂-鞘磷脂比值（L/S）。
所有RDS病例的板层小体计数均为55,000/微升或更低，L/S为2.2或更低；无RDS病例中59%的计数大于55,000/微升，正常病例中70%的L/S高于2.2。
使用板层小体计数作为预测胎儿肺成熟度的快速筛查检测方法是合理的。结果不成熟时应采用更特异的检测方法，如L/S检测。
