家族性乳腺-卵巢癌基因在17q12-q21染色体上的遗传异质性与定位
Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.
作者信息
Smith S A, Easton D F, Ford D, Peto J, Anderson K, Averill D, Stratton M, Ponder M, Pye C, Ponder B A
机构信息
Department of Pathology, University of Cambridge, England.
出版信息
Am J Hum Genet. 1993 Apr;52(4):767-76.
Abstract
In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.
摘要
在一项对31个乳腺癌家族和12个乳腺-卵巢癌家族的研究中，我们已获得明确证据，表明卵巢癌家族与17号染色体q臂上的标记存在连锁关系（在θ=0.04时最大lod值为3.34），但在无卵巢癌的家族中仅有微弱证据。重组事件表明该基因位于D17S588和D17S250之间。
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