对29个瑞典乳腺癌家族中17号染色体长臂上的标记进行连锁分析。
Linkage analysis with markers on 17q in 29 Swedish breast cancer families.
作者信息
Lindblom A, Rotstein S, Nordenskjöld M, Larsson C
机构信息
Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
出版信息
Am J Hum Genet. 1993 Apr;52(4):749-53.
Recently, a putative breast cancer gene was localized to the long arm of chromosome 17. A collaboration study was undertaken to confirm linkage, to further map the gene, and to determine to what extent breast cancer families are linked to this locus. The Swedish material consisted of 29 breast cancer families in which 68 affected members were studied. Linkage analysis of breast cancer susceptibility was performed with a number of markers on 17q. In this material a weakly positive LOD score in favor of linkage was observed in a subgroup of families with early onset, while no such linkage was observed in a subgroup of families with late onset.
最近，一个假定的乳腺癌基因被定位到17号染色体长臂上。开展了一项合作研究，以确认连锁关系，进一步绘制该基因图谱，并确定乳腺癌家族与该基因座的连锁程度。瑞典的样本包括29个乳腺癌家族，其中68名患病成员接受了研究。利用17q上的多个标记对乳腺癌易感性进行了连锁分析。在这个样本中，在早发型家族亚组中观察到一个支持连锁的弱阳性LOD评分，而在晚发型家族亚组中未观察到这种连锁。
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