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[纳瓦拉研究(PECNA)。高脂血症IV。纳瓦拉婴幼儿及青少年人群中的高脂血症患病率。基于年龄、性别和医疗可及性的差异]

[The Navarra study (PECNA). Hyperlipidemia IV. Prevalence of hyperlipidemia in the infant- and juvenile population of Navarra. Variations based on age, gender and health care accessibility].

作者信息

Elcarte López R, Villa Elizaga I, Sada Goñi J, Gasco Eguiluz M, Oyarzabal Irigoyen M, Sola Mateos A, García Ibero C, Martínez González A, Ferrer Giménez M, Fontaneda Estíbaliz A

机构信息

Unidad de Endocrinología Pediátrica, Hospital Virgen del Camino, Pamplona, Navarra.

出版信息

An Esp Pediatr. 1993 Mar;38(3):205-12.

PMID:8460836
Abstract

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, lipids and lipoproteins were analyzed in 5,829 children of both sexes. These children were between 4 and 17 years of age and were randomly selected from the school population of our community. In this article, we analyze the prevalence of lipid risk, according to its different definitions, among children and adolescents in Navarra, and its variations related to age, sex and sanitary area. The prevalence of hypercholesterolemia (C > 200 mg/dl) among children and adolescents, aged 4 to 17 years, is very high: 21.07% +/- 0.54%. In spite of having high serum levels of HDL, the lipid risk measured by the risk quotient LDL/HDL > 2.2 is still very high: 15-70% +/- 0.49%. If we define the lipid risk during childhood and adolescence by the quotient LDL/HDL > 2.2, male adolescents turn out to be the group with the highest risk. This phenomenon coincides with the results of the epidemiological studies made among adults. Nevertheless, they do not coincide with these results if the lipid risk is defined by C > 200 mg/dl. In our opinion, during infancy and adolescence, the lipid risk is better defined by the quotient LDL/HDL > 2.2.

摘要

作为纳瓦拉儿童和青少年心血管危险因素流行病学研究的一部分,对5829名男女儿童的脂质和脂蛋白进行了分析。这些儿童年龄在4至17岁之间,是从我们社区的学校人群中随机挑选出来的。在本文中,我们根据不同定义分析了纳瓦拉儿童和青少年中脂质风险的患病率,以及其与年龄、性别和卫生区域的关系。4至17岁儿童和青少年中高胆固醇血症(C>200mg/dl)的患病率非常高:21.07%±0.54%。尽管高密度脂蛋白血清水平较高,但通过风险商数低密度脂蛋白/高密度脂蛋白>2.2衡量的脂质风险仍然很高:15 - 70%±0.49%。如果我们通过低密度脂蛋白/高密度脂蛋白>2.2的商数来定义儿童期和青少年期的脂质风险,男性青少年是风险最高的群体。这一现象与对成年人进行的流行病学研究结果一致。然而,如果脂质风险通过C>200mg/dl来定义,它们与这些结果并不一致。我们认为,在婴儿期和青少年期,脂质风险通过低密度脂蛋白/高密度脂蛋白>2.2的商数来定义更为合适。

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