Brown G G, Garcia J H, Gdowski J W, Levine S R, Helpern J A
Department of Neuropsychology, Henry Ford Health Science Center, Detroit, Mich. 48202.
Arch Neurol. 1993 Apr;50(4):384-8. doi: 10.1001/archneur.1993.00540040046012.
We report the results of brain metabolic studies (using magnetic resonance spectroscopy) in three groups of individuals: (1) demented patients with multiple subcortical ischemic lesions (n = 18); (2) nondemented, age-matched controls (n = 21); and (3) demented patients with neurodegenerative disease, probably of the Alzheimer type (n = 19). Patients with dementia with subcortical vascular lesions, as demonstrated by appropriate imaging studies, had an increase of phosphate energy charge in areas of the cerebral cortex (especially prominent in the frontal regions) superficial to and excluded from the subcortical lesions. We hypothesize that this increased energy charge might be caused by reduced metabolic activity of disconnected brain tissue or by astrocytic hypertrophy and hyperplasia that accompanies subtle ischemic, cortical alterations.
我们报告了三组个体的脑代谢研究结果（使用磁共振波谱法）：（1）患有多个皮质下缺血性病变的痴呆患者（n = 18）；（2）非痴呆、年龄匹配的对照组（n = 21）；以及（3）可能为阿尔茨海默型的神经退行性疾病痴呆患者（n = 19）。经适当影像学研究证实，患有皮质下血管病变的痴呆患者，其大脑皮质区域（尤其是额叶区域）的磷酸盐能量电荷增加，这些区域位于皮质下病变的浅层且未受其影响。我们推测，这种能量电荷增加可能是由于断开连接的脑组织代谢活动降低，或者是伴随轻微缺血性皮质改变的星形胶质细胞肥大和增生所致。
