耐喹诺酮空肠弯曲菌对新型大环内酯类抗生素的体外敏感性

In vitro susceptibility of quinolone-resistant Campylobacter jejuni to new macrolide antibiotics.

作者信息

Endtz H P, Broeren M, Mouton R P

机构信息

Department of Clinical Microbiology, University Hospital Rotterdam-Dijkzigt, The Netherlands.

出版信息

Eur J Clin Microbiol Infect Dis. 1993 Jan;12(1):48-50. doi: 10.1007/BF01997058.

DOI:10.1007/BF01997058

PMID:8462563

Abstract

The MICs of erythromycin and three new macrolide antibiotics were determined for 36 quinolone-susceptible and 106 quinolone-resistant Campylobacter jejuni. The MIC90 values of azithromycin, clarithromycin, roxithromycin and erythromycin were 0.5, 4, 16 and 4 mg/l respectively. No difference was found between macrolide activity against the quinolone-susceptible and the quinolone-resistant strains. Clarithromycin and especially azithromycin might eventually replace erythromycin for the treatment of Campylobacter jejuni infections in view of their pharmacological properties.

摘要

测定了红霉素及三种新型大环内酯类抗生素对36株喹诺酮敏感和106株喹诺酮耐药空肠弯曲菌的最低抑菌浓度（MIC）。阿奇霉素、克拉霉素、罗红霉素和红霉素的MIC90值分别为0.5、4、16和4mg/L。在对喹诺酮敏感菌株和喹诺酮耐药菌株的大环内酯活性方面未发现差异。鉴于克拉霉素尤其是阿奇霉素的药理学特性，它们最终可能会取代红霉素用于治疗空肠弯曲菌感染。