Endtz H P, Ruijs G J, van Klingeren B, Jansen W H, van der Reyden T, Mouton R P
Department of Medical Microbiology, University Hospital, Leiden, The Netherlands.
J Antimicrob Chemother. 1991 Feb;27(2):199-208. doi: 10.1093/jac/27.2.199.
Eight hundred and eighty-three strains of Campylobacter spp. isolated between 1982 and 1989 from human stools and poultry products were screened for quinolone resistance. In this period the prevalence of resistant strains isolated from poultry products increased from 0% to 14%. During the same period the prevalence in man increased from 0% to 11%. The emergence of quinolone resistance has implications for the identification of campylobacter up to species level: the susceptibility for nalidixic acid can no longer be used as a criterion for identification in the laboratory. The rapid emergence of resistant campylobacter may also have important implications for the treatment and prophylaxis of diarrhoeal disease. The increase of quinolone resistance coincides with the increasing use of fluoroquinolones in human and veterinary medicine. Extensive use of enrofloxacin in poultry and the almost exclusive transmission route of campylobacter from chicken to man, in The Netherlands, suggests that the resistance observed is mainly due to the use of enrofloxacin in the poultry industry.
对1982年至1989年间从人类粪便和家禽产品中分离出的883株弯曲杆菌属菌株进行了喹诺酮耐药性筛查。在此期间，从家禽产品中分离出的耐药菌株的比例从0%上升到了14%。同一时期，人类中的耐药比例从0%上升到了11%。喹诺酮耐药性的出现对弯曲杆菌至种水平的鉴定有影响：在实验室中，萘啶酸敏感性不再能作为鉴定的标准。耐药弯曲杆菌的迅速出现可能对腹泻病的治疗和预防也有重要影响。喹诺酮耐药性的增加与氟喹诺酮类药物在人类医学和兽医学中的使用增加相吻合。在荷兰，恩诺沙星在家禽中的广泛使用以及弯曲杆菌从鸡到人的几乎唯一传播途径表明，观察到的耐药性主要是由于家禽业使用恩诺沙星所致。
