空肠弯曲菌氟喹诺酮耐药菌株对11种口服抗菌药物的敏感性
Susceptibilities of fluoroquinolone-resistant strains of Campylobacter jejuni to 11 oral antimicrobial agents.
作者信息
Gomez-Garces J L, Cogollos R, Alos J L
机构信息
Servicio de Microbiologia, Hospital de Mostoles, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 1995 Feb;39(2):542-44. doi: 10.1128/AAC.39.2.542.
Abstract
The resistance of Campylobacter jejuni strains to the fluoroquinolones is increasingly frequent, and in our area it reaches nearly 50%. We studied the susceptibilities of 60 of these strains to 11 oral antibiotics. All strains except one were susceptible to the macrolides tested, with azithromycin being the most active agent tested. Of the rest of the antibiotics studied, amoxicillin-clavulanic acid, clindamycin, and fosfomycin displayed good in vitro activities. Knowledge of the susceptibilities of these microorganisms to a varied group of oral agents is necessary in view of the appearance of multiresistant strains, such as those included in our series.
摘要
空肠弯曲菌菌株对氟喹诺酮类药物的耐药性越来越常见，在我们地区这一比例接近50%。我们研究了其中60株菌株对11种口服抗生素的敏感性。除1株外，所有菌株对所测试的大环内酯类药物敏感，阿奇霉素是所测试药物中活性最强的。在所研究的其他抗生素中，阿莫西林-克拉维酸、克林霉素和磷霉素显示出良好的体外活性。鉴于多重耐药菌株的出现，比如我们研究系列中包含的那些菌株，了解这些微生物对多种口服药物的敏感性是必要的。
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