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粟酒裂殖酵母gtp1基因序列及一类新型假定GTP结合蛋白家族的鉴定。

Sequence of the Schizosaccharomyces pombe gtp1 gene and identification of a novel family of putative GTP-binding proteins.

作者信息

Hudson J D, Young P G

机构信息

Department of Biology, Queen's University, Kingston, Ontario, Canada.

出版信息

Gene. 1993 Mar 30;125(2):191-3. doi: 10.1016/0378-1119(93)90327-y.

DOI:10.1016/0378-1119(93)90327-y
PMID:8462872
Abstract

A new gene, gtp1, has been identified by sequence analysis in Schizosaccharomyces pombe. The open reading frame was identified downstream from the stf1 locus. The deduced GTP1 protein has strong sequence similarity to a family of putative GTP-binding proteins from Halobacterium cutirubrum, Bacillus subtilis, Drosophila melanogaster and mouse. The conserved P-loop phosphate-binding motif places gtp1 in a family separate from previously described groups of such proteins.

摘要

通过对粟酒裂殖酵母的序列分析，鉴定出了一个新基因gtp1。开放阅读框在stf1基因座下游被鉴定出来。推导的GTP1蛋白与来自盐红嗜盐菌、枯草芽孢杆菌、黑腹果蝇和小鼠的一类假定的GTP结合蛋白具有很强的序列相似性。保守的P环磷酸结合基序使gtp1属于一个与先前描述的此类蛋白质组不同的家族。

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