Sposto M R, Scully C, de Almeida O P, Jorge J, Graner E, Bozzo L
Department of Oral Diagnosis, Faculty of Odontology, UNESP, Araraquara, Brazil.
Oral Surg Oral Med Oral Pathol. 1993 Apr;75(4):461-5. doi: 10.1016/0030-4220(93)90171-y.
Paracoccidioidomycosis (South American blastomycosis) is an uncommon, progressive systemic mycosis, virtually only seen in persons who have visited Latin America. Reports of oral lesions are extremely rare in the English-language literature. Thirty-six adults with oral lesions as the first sign of paracoccidioidomycosis are described; this appears to be the largest series in the dental literature. All had chronic proliferative mulberry-like ulcerated oral lesions; the diagnosis was confirmed histologically. The gingiva or alveolar process was the typical site, but lesions were also seen particularly on the palate and lip. Most of the patients proved to have detectable pulmonary involvement. Patients with lesions in the oropharynx, tongue, or floor of mouth all had confirmed pulmonary lesions.
副球孢子菌病（南美芽生菌病）是一种罕见的进行性系统性真菌病，实际上仅见于去过拉丁美洲的人。英文文献中关于口腔病变的报道极为罕见。本文描述了36例以口腔病变为副球孢子菌病首发症状的成年人；这似乎是牙科文献中最大的病例系列。所有患者均有慢性增殖性桑葚样溃疡性口腔病变；组织学检查确诊。牙龈或牙槽突是典型部位，但在腭部和唇部也可见病变。大多数患者经证实有肺部受累。口咽、舌或口底有病变的患者均有确诊的肺部病变。
