恶性疟原虫染色体外35kb环状DNA中大亚基rRNA基因的序列与组织
Sequence and organization of large subunit rRNA genes from the extrachromosomal 35 kb circular DNA of the malaria parasite Plasmodium falciparum.
作者信息
Gardner M J, Feagin J E, Moore D J, Rangachari K, Williamson D H, Wilson R J
机构信息
National Institute for Medical Research, Mill Hill, London, UK.
出版信息
Nucleic Acids Res. 1993 Mar 11;21(5):1067-71. doi: 10.1093/nar/21.5.1067.
The malaria parasite Plasmodium falciparum carries an extrachromosomal 35 kb circular DNA molecule of unknown provenance. A striking feature of the circle is a palindromic sequence of genes for subunit rRNAs and several tRNAs, spanning ca. 10.5 kb. The palindrome has an intriguing resemblance to the inverted repeat of plastid genomes, and the sequence and putative secondary structure of the malarial large subunit (LSU) rRNA described in this report were used as the basis of a phylogenetic study. The malarial rRNA was found to be highly divergent in comparison with a selected group of chloroplast LSU rRNAs but was more closely related to them than to mitochondrial LSU rRNA genes.
疟原虫恶性疟原虫携带一个来源不明的35 kb染色体外环状DNA分子。该环状物的一个显著特征是亚基rRNA和几种tRNA的基因的回文序列，跨度约为10.5 kb。该回文结构与质体基因组的反向重复序列有着有趣的相似性，本报告中描述的疟疾大亚基（LSU）rRNA的序列和推定二级结构被用作系统发育研究的基础。与一组选定的叶绿体LSU rRNA相比，发现疟疾rRNA高度分化，但与它们的关系比与线粒体LSU rRNA基因的关系更密切。
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