von Hartitzsch B, Kerr D N, Morley G, Marks B
Nephron. 1977;18(1):13-20. doi: 10.1159/000180761.
Plasma levels of testosterone-like substances (TLS) were depressed in seven patients with chronic renal failure. Intramuscular testosterone (as Sustanon 250 once a week) elevated plasma TLS levels to above normal throughout the week with an initial high peak. Sublingual testosterone produced a high but brief peak in TLS. Results were similar in renal failure patients and normal controls. A controlled trial of weekly Sustanon 250 in 24 regular dialysis patients produced a significant increase in haemoglobin from 6.8 to 8.2 g/dl. Side effects were mainly mild and acceptable but one patient developed priapism and another a large haematoma. The discriminate use of androgens is recommended for anaemic male patients on regular haemodialysis.
7例慢性肾衰竭患者血浆中睾酮样物质（TLS）水平降低。肌肉注射睾酮（如每星期一次的长效睾酮250）使血浆TLS水平在一周内持续高于正常水平，并出现一个初始高峰。舌下含服睾酮使TLS出现一个高但短暂的峰值。肾衰竭患者和正常对照的结果相似。一项针对24例规律透析患者的每周一次长效睾酮250对照试验显示，血红蛋白从6.8克/分升显著增加至8.2克/分升。副作用主要为轻度且可接受，但有1例患者出现阴茎异常勃起，另1例出现大血肿。建议对接受规律血液透析的贫血男性患者谨慎使用雄激素。
