Sabbah A, Buchmann C, Lauret M G, Drouet M
Laboratoire d'Immuno-Allergologie, C.H.U., Angers.
Allerg Immunol (Paris). 1993 Feb;25(2):48-54.
IgE has two types of receptors: high affinity RFc sigma I and low affinity RFc sigma II. The latter may be studied by flow cytometry by the membrane marker CD23 (mCD23), expressed on B and T cells, monocytes, macrophages, Langerhans cells, eosinophils and platelets. Soluble CD23 (sCD23) corresponds with the extracellular C terminal domain of mCD23. The aim of the study was to search for a correlation between the levels of mCD23 and sCD23, comparatively with IgE, eosinophils, eosinophil cationic protein (ECP) and to the cytokines IL2, IL4 and IL6. 78 patients took part in the study, divided into two groups: Group 1 = atopics (n = 61); Group 2 = controls (n = 17). The majority presented with rhinitis, asthma, atopic dermatitis isolated or associated. The results showed a highly significant correlation between mCD23 and sCD23 compared with the control group. There was also a statistically significant increase for mCD23, sCD23, cytokines IL2, IL4 and IL6, mediator ECP in parallel with eosinophils and total IgE. This study confirms amongst other things the rise in IL4 in atopy and the correlation between the level of ECP and that of eosinophils, and that there is an overall correlation between mCD23 and sCD23.
免疫球蛋白E（IgE）有两种类型的受体：高亲和力的FcεRI和低亲和力的FcεRII。后者可以通过流式细胞术，利用在B细胞、T细胞、单核细胞、巨噬细胞、朗格汉斯细胞、嗜酸性粒细胞和血小板上表达的膜标志物CD23（mCD23）来进行研究。可溶性CD23（sCD23）与mCD23的细胞外C末端结构域相对应。本研究的目的是寻找mCD23和sCD23水平之间的相关性，并与IgE、嗜酸性粒细胞、嗜酸性粒细胞阳离子蛋白（ECP）以及细胞因子白细胞介素2（IL2）、白细胞介素4（IL4）和白细胞介素6进行比较。78名患者参与了该研究，分为两组：第1组 = 特应性患者（n = 61）；第2组 = 对照组（n = 17）。大多数患者表现为鼻炎、哮喘、孤立性或合并性特应性皮炎。结果显示，与对照组相比，mCD23和sCD23之间存在高度显著的相关性。mCD23、sCD23、细胞因子IL2、IL4和IL6、介质ECP以及嗜酸性粒细胞和总IgE也有统计学上的显著增加。本研究除其他外证实了特应性疾病中IL4的升高以及ECP水平与嗜酸性粒细胞水平之间的相关性，并且mCD23和sCD23之间存在总体相关性。
