Daher S, Santos L M, Solé D, De Lima M G, Naspitz C K, Musatti C C
Department of Pediatrics, Universidade Federal de São Paulo, Brazil.
J Investig Allergol Clin Immunol. 1995 Sep-Oct;5(5):251-4.
IL-4 is an essential mediator of IgE synthesis; it also upregulates the expression of the low affinity receptor for IgE (CD23) and its release in soluble form (sCD23). The involvement of IL-4 and sCD23 on the IgE synthesis control has been observed in experimental studies. IL-4 and sCD23 serum levels in asthmatic atopic children were determined in order to investigate a possible correlation between these factors and IgE levels. IL-4, total sCD23 and Dermatophagoides pteronyssinus specific IgE were determined in the serum of 19 asthmatic atopic children (aged 7 to 14) and in 13 age-matched controls. Since sCD23 may present an age-dependent variation, sCD23 and IL-4 serum levels were evaluated in 20 "wheezy babies." IL-4 serum levels were significantly higher in patients as compared to controls, whereas there was no significant difference between them concerning sCD23 levels. sCD23 levels were, however, significantly higher among "wheezy babies" as compared to atopic and nonatopic children. There was no correlation between IL-4 and sCD23 serum levels, nor between any of these factors and IgE levels in all groups. In conclusion, the enhanced IL-4 levels suggest that atopic patients have a preferential activation of Th2 subset. CD23 expression is markedly influenced by age.
白细胞介素-4是免疫球蛋白E合成的关键介质；它还上调免疫球蛋白E低亲和力受体（CD23）的表达及其可溶性形式（sCD23）的释放。在实验研究中已观察到白细胞介素-4和sCD23参与免疫球蛋白E合成的调控。测定了哮喘特应性儿童的白细胞介素-4和sCD23血清水平，以研究这些因素与免疫球蛋白E水平之间可能存在的相关性。测定了19名哮喘特应性儿童（7至14岁）和13名年龄匹配的对照者血清中的白细胞介素-4、总sCD23和屋尘螨特异性免疫球蛋白E。由于sCD23可能存在年龄依赖性变化，因此在20名“喘息婴儿”中评估了sCD23和白细胞介素-4的血清水平。与对照组相比，患者的白细胞介素-4血清水平显著更高，而他们之间的sCD23水平没有显著差异。然而，与特应性和非特应性儿童相比，“喘息婴儿”中的sCD23水平显著更高。在所有组中，白细胞介素-4和sCD23血清水平之间以及这些因素中的任何一个与免疫球蛋白E水平之间均无相关性。总之，白细胞介素-4水平升高表明特应性患者的辅助性T细胞2亚群优先被激活。CD23的表达受年龄的显著影响。
