Viñas P, Lopez Garcia I, Martinez Gil J A
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
J Pharm Biomed Anal. 1993 Jan;11(1):15-20. doi: 10.1016/0731-7085(93)80144-p.
A flow injection analysis procedure with chemiluminescence detection for the determination of both thiol-containing drugs and the amino acid cysteine is described. Procedures are based on the inhibition by the drugs of the chemiluminescence generated in the copper-catalysed oxidation of luminol by hydrogen peroxide. The proposed methods were applied to the determination of cysteine, N-acetylcysteine, penicillamine, 2-mercaptopropionylglycine and thiouracil in pharmaceuticals.
