Nakadaira K, Tsukada K, Sakaguchi T, Shirai Y, Kurosaki I, Ohtake M, Yoshida K, Muto T
Department of Surgery, Niigata University School of Medicine, Japan.
Surg Today. 1993;23(3):277-9. doi: 10.1007/BF00309242.
Portal venous flow (PVF) and portal venous pressure (PVP) were examined after the jugular or portal injection of Prostaglandin E1 (PGE) in rats partially hepatectomized by either 40% or 66%. In the 66% hepatectomized animals, the jugular injection of PGE at 5.0 micrograms/kg/min produced an increase in PVF concomitant with a fall in systemic arterial pressure (SAP), while PVP remained unchanged. The portal injection of PGE at 0.5 micrograms/kg/min increased PVF to a level equivalent to that evoked by the jugular injection of 5.0 micrograms/kg/min PGE, without any change in SAP. PVP was reduced synchronistically with an increase in PVF. The PVF response to a portal injection of PGE at 0.5 micrograms/kg/min was not reproduced in liver intact rats. These results suggest that PGE is potent in increasing PVF in the partially resected condition of the liver and that the portal vascular bed is involved in this response.
在40%或66%部分肝切除的大鼠中，经颈静脉或门静脉注射前列腺素E1（PGE）后，检测门静脉血流（PVF）和门静脉压力（PVP）。在66%肝切除的动物中，以5.0微克/千克/分钟的速度经颈静脉注射PGE，可使PVF增加，同时体循环动脉压（SAP）下降，而PVP保持不变。以0.5微克/千克/分钟的速度经门静脉注射PGE，可使PVF增加至与以5.0微克/千克/分钟的速度经颈静脉注射PGE所引起的水平相当，且SAP无任何变化。PVP随PVF增加而同步降低。在肝脏完整的大鼠中，未重现以0.5微克/千克/分钟的速度经门静脉注射PGE时的PVF反应。这些结果表明，PGE在肝脏部分切除状态下能有效增加PVF，且门静脉血管床参与了这一反应。
