High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members.

作者信息

Hoovers J M, Redeker E, Speleman F, Höppener J W, Bhola S, Bliek J, van Roy N, Leschot N J, Westerveld A, Mannens M

机构信息

Institute of Human Genetics, University of Amsterdam, The Netherlands.

出版信息

Genomics. 1993 Mar;15(3):525-9. doi: 10.1006/geno.1993.1104.

We report the high-resolution localization of the human calcitonin/CGRP genes, CALCA, CALCB, and the pseudogene CALCP, to a 220-kb SacII fragment on chromosome 11p15.2-p15.1, using prometaphase fluorescence in situ hybridization (FISH), two-color interphase FISH, and pulsed-field gel electrophoresis analysis. The related islet amyloid polypeptide (IAPP) gene was assigned to human chromosome 12p12.3-p12.1. The results support an evolutionary relationship between the calcitonin/CGRP genes and the IAPP gene and between parts of human chromosomes 11 and 12.