消化菌素，一种由放线菌产生的新型法尼基蛋白转移酶抑制剂。II. 消化菌素E的结构解析。
Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E.
作者信息
Shiomi K, Yang H, Inokoshi J, Van der Pyl D, Nakagawa A, Takeshima H, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1993 Feb;46(2):229-34. doi: 10.7164/antibiotics.46.229.
PMID:8468236
Abstract
Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.
摘要
通过核磁共振研究阐明了新型法尼基转移酶抑制剂pepticinnamin E的结构。Pepticinnamin E由五个氨基酸和邻戊烯基肉桂酸组成，分子量为907。该化合物的C端甘氨酰丝氨酸呈环化二酮哌嗪形式。
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