Minot R, Luthringer R, Macher J P
Departmental Psychiatric Hospital, Rouffach, France.
Int Clin Psychopharmacol. 1993 Jan;7(3-4):181-9. doi: 10.1097/00004850-199300730-00009.
The effects of moclobemide, 450 mg/day, on sleep were investigated in 12 patients with major depression. The study was carried out over six weeks, divided into three periods: (1) treatment for one week with placebo and measurement to obtain baseline values; (2) treatment with moclobemide for four weeks; and (3) one week withdrawal period. Polygraphic sleep recording, all-night sleep-EEG spectral analysis, and diurnal EEG vigilance mapping were used to determine the effects of this antidepressant. An activating effect was observed, most marked during the early phase of treatment. The most noticeable effects were on REM sleep, affecting polysomnographic and spectral sleep EEG parameters. A REM sleep habituation phenomenon was observed, and a slight REM sleep rebound effect occurred early during withdrawal. The observed neuroelectrophysiological changes appear to be specific for moclobemide and differ from those brought about by other antidepressants.
对12例重度抑郁症患者研究了每天450毫克吗氯贝胺对睡眠的影响。该研究历时六周，分为三个阶段：（1）使用安慰剂治疗一周并进行测量以获取基线值；（2）使用吗氯贝胺治疗四周；（3）一周的撤药期。采用多导睡眠记录、整夜睡眠脑电图频谱分析和日间脑电图警觉性图谱来确定这种抗抑郁药的效果。观察到一种激活作用，在治疗早期最为明显。最显著的影响是对快速眼动睡眠，影响多导睡眠图和频谱睡眠脑电图参数。观察到快速眼动睡眠习惯化现象，撤药早期出现轻微的快速眼动睡眠反跳效应。观察到的神经电生理变化似乎是吗氯贝胺特有的，与其他抗抑郁药引起的变化不同。
