Félix A, Fonseca I, Soares J
Department of Morphological Pathology, Instituto Portugês de Oncologia de Francisco Gentil, Lisbon.
J Surg Oncol. 1993 Apr;52(4):217-22. doi: 10.1002/jso.2930520404.
We studied nine cases of oncocytic tumors of salivary gland type in order to evaluate their clinico-pathologic profiles and nuclear DNA patterns as criteria for the differential diagnosis between benign and malignant forms. The tumors were located at the parotid gland, palate, and orbit. The age of the patients ranged between 35 and 85 years and the sex ratio (F:M) was 1:0.8. Seven tumors were capsulated and had typical cytology: they were composed of polyhedrical cells with large, eosinophilic, and granular cytoplasm and dark nucleus. The remaining two tumors exhibited malignancy criteria for the oncocytic tumors: atypia, pleomorphism, and mitosis. The evaluation of the nuclear DNA content was also distinct: benign tumors had a DNA diploid pattern and the malignant neoplasms displayed a DNA aneuploid pattern. These observations point to DNA nuclear assessment as an additional criterion to discriminate neoplasms with divergent clinical behavior and prognosis.
我们研究了9例涎腺型嗜酸性细胞瘤，以评估其临床病理特征及核DNA模式，作为鉴别良恶性肿瘤的标准。肿瘤位于腮腺、腭部和眼眶。患者年龄在35至85岁之间，性别比（女：男）为1:0.8。7例肿瘤有包膜且具有典型细胞学特征：由多角形细胞组成，胞质大、嗜酸性、颗粒状，核深染。其余2例肿瘤表现出嗜酸性细胞瘤的恶性标准：异型性、多形性和有丝分裂。核DNA含量评估也不同：良性肿瘤呈DNA二倍体模式，恶性肿瘤呈DNA非整倍体模式。这些观察结果表明，DNA核评估可作为区分具有不同临床行为和预后的肿瘤的附加标准。
