Soininen H, Partanen J, Jousmäki V, Helkala E L, Vanhanen M, Majuri S, Kaski M, Hartikainen P, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Neuroscience. 1993 Mar;53(1):57-63. doi: 10.1016/0306-4522(93)90284-m.
We studied quantitative electroencephalogram and neuropsychological performance in an aging series of 31 patients with Down's syndrome and compared the findings with those of 36 patients with probable Alzheimer's disease and age-matched controls. We found an age-related decline of cortical functions and slowing of the electroencephalogram in Down's syndrome patients aged from 20 to 60 years. Slowing of the electroencephalogram, i.e. the decrease of the peak frequency, was significantly related to Mini-Mental status scores, and visual, praxic and speech functions, as well as memory in the Down patients, similar to the Alzheimer patients. Similar correlations were not demonstrated for young or elderly controls. This study provides neuropsychological and electrophysiological data to suggest that studying Down's syndrome patients of different ages can serve as a model for progression of Alzheimer's disease.
我们研究了31例唐氏综合征老年患者的定量脑电图和神经心理表现，并将结果与36例可能患有阿尔茨海默病的患者及年龄匹配的对照组进行比较。我们发现，年龄在20至60岁的唐氏综合征患者存在与年龄相关的皮质功能衰退和脑电图减慢。脑电图减慢，即峰值频率降低，与简易精神状态评分、视觉、运用和言语功能以及唐氏患者的记忆显著相关，这与阿尔茨海默病患者相似。在年轻或老年对照组中未发现类似的相关性。这项研究提供了神经心理学和电生理学数据，表明研究不同年龄段的唐氏综合征患者可作为阿尔茨海默病进展的模型。
