Roguin N, Greif Z, Schneeweiss A, Yahalom M, Hartman C, Saab K, Glusman A, Milgram E, Shasha S
Department of Cardiology, Western Galilee Regional Hospital, Nahariya, Israel.
Pediatr Cardiol. 1993 Mar;14(2):86-8. doi: 10.1007/BF00796985.
During an epidemic of acute glomerulonephritis (AGN) 15 patients were studied by M-mode, cross-sectional, and Doppler echocardiography. All 15 patients had the classical signs of the disease including hematuria, proteinuria, edema, and consistent laboratory findings. There were 10 boys and five girls with a mean age of 8 years. Ten of the 15 patients had an enlarged left atrium and five of these 10 also had transient mild to moderate mitral regurgitation. In the five patients with mitral regurgitation the ratio of left atrium/aorta was 1.48; in the five patients with an enlarged left atria without evidence of mitral regurgitation the left atrium/aorta ratio was 1.34. All the patients had normal left ventricular dimensions, as well as ejection and shortening fractions. The findings of left atrial enlargement and mitral regurgitation disappeared gradually in all patients within 3 months. There was no correlation between the level of systemic blood pressure and the development of mitral regurgitation. A possible cause for these changes is fluid overload in the oliguric phase of the acute glomerulonephritis. The changes are transient and probably functional. There was no significant mitral valve or left atrial anomaly 3 and 6 months after hospital discharge.
在一次急性肾小球肾炎（AGN）流行期间，对15例患者进行了M型、横断面和多普勒超声心动图检查。所有15例患者均有该疾病的典型体征，包括血尿、蛋白尿、水肿以及一致的实验室检查结果。其中有10名男孩和5名女孩，平均年龄为8岁。15例患者中有10例左心房增大，这10例中的5例还伴有短暂的轻度至中度二尖瓣反流。在有二尖瓣反流的5例患者中，左心房/主动脉比值为1.48；在左心房增大但无二尖瓣反流证据的5例患者中，左心房/主动脉比值为1.34。所有患者的左心室大小、射血分数和缩短分数均正常。所有患者左心房增大和二尖瓣反流的表现均在3个月内逐渐消失。全身血压水平与二尖瓣反流的发生之间无相关性。这些变化的一个可能原因是急性肾小球肾炎少尿期的液体超负荷。这些变化是短暂的，可能是功能性的。出院后3个月和6个月时，二尖瓣或左心房无明显异常。
