McEntee M F, Horton S, Blue J, Meuten D J
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville.
Vet Pathol. 1993 Mar;30(2):195-203. doi: 10.1177/030098589303000213.
Morphologic and biologic features of five feline granulated round cell tumours were compared with those previously reported to be of globule leukocyte and large granular lymphocyte origin. The five cats ranged from 6 to 9 years of age and presented with nonspecific gastrointestinal signs. Four of the five cats were tested for feline leukemia virus and were negative by enzyme-linked immunosorbent assay. The neoplastic process involved the abdominal cavity in all cases, with a predilection for the distal small intestine and mesentery. The liver and peripheral and thoracic lymphoid tissues were also sporadically affected. Neoplastic round cells contained 0.5-1.5-microns eosinophilic cytoplasmic granules that were difficult to discern on causal observation with hematoxylin and eosin stain but were deep blue and easily visualized when stained with phosphotungstic acid-hematoxylin. In two cases, epithelium in the affected ileum and liver contained unusually large numbers of apparently normal globule leukocytes. Ultrastructurally, the tumor granules tended to cluster at one nuclear pole and were spindle to round in shape with variably dense contents. Some granules contained a dense "cap" at one end or internal crystalloid bars that distorted the granule membrane. The tumors reported herein are similar to all three of the previously reported feline granulated round cell tumors and probably have a common cellular origin.
将五只猫的颗粒状圆形细胞瘤的形态学和生物学特征与先前报道的源自球样白细胞和大颗粒淋巴细胞的肿瘤特征进行了比较。这五只猫年龄在6至9岁之间，均表现出非特异性胃肠道症状。五只猫中的四只进行了猫白血病病毒检测，酶联免疫吸附试验结果均为阴性。所有病例的肿瘤病变均累及腹腔，以远端小肠和肠系膜最为常见。肝脏以及外周和胸部淋巴组织也偶有受累。肿瘤性圆形细胞含有0.5至1.5微米的嗜酸性细胞质颗粒，苏木精和伊红染色时在大体观察下难以辨别，但用磷钨酸苏木精染色时呈深蓝色且易于观察。在两例病例中，受累回肠和肝脏的上皮中含有异常大量的明显正常的球样白细胞。超微结构上，肿瘤颗粒倾向于聚集在一个核极，呈纺锤形至圆形，内容物密度不一。一些颗粒一端含有致密的“帽”或内部晶体条，使颗粒膜变形。本文报道的肿瘤与先前报道的所有三种猫颗粒状圆形细胞瘤相似，可能具有共同的细胞起源。
