Kariya K, Konno A, Ishida T
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Vet Pathol. 1997 Mar;34(2):156-9. doi: 10.1177/030098589703400210.
Tumors composed of discrete round cells with large eosinophilic granules in their cytoplasm were observed in four cats. These cats were presented with severe gastrointestinal signs, including anorexia, vomiting, and diarrhea. The exploratory laparotomy in two cats and necropsy in the other two revealed thickening and perforation of the intestinal walls, enlargement of the mesenteric, ileocolic, and/or colic lymph nodes, and splenomegaly. Histologically, there was severe and disseminated infiltration of the tumor cells in the affected organs. In the two cats necropsied, the spleen and the jejunal mucosa appeared to be the primary organs involved. The tumor cells of all the cats showed the pore-forming protein (perforin)-like immunoreactivity unique to the cytotoxic lymphocytes but failed to show histamine immunoreactivity. These results indicate that the tumor cells were derived from large granular lymphocytes and that perforinlike immunoreactivity may be a useful marker for histologic diagnosis of feline large granular lymphoma.
在四只猫身上观察到由胞质内有大嗜酸性颗粒的离散圆形细胞组成的肿瘤。这些猫出现严重的胃肠道症状，包括厌食、呕吐和腹泻。对两只猫进行的剖腹探查术以及对另外两只猫进行的尸检显示，肠壁增厚和穿孔、肠系膜、回结肠和/或结肠淋巴结肿大以及脾肿大。组织学上，肿瘤细胞在受影响器官中有严重且弥漫性浸润。在进行尸检的两只猫中，脾脏和空肠黏膜似乎是主要受累器官。所有猫的肿瘤细胞均显示出细胞毒性淋巴细胞特有的穿孔素样免疫反应性，但未显示组胺免疫反应性。这些结果表明，肿瘤细胞源自大颗粒淋巴细胞，且穿孔素样免疫反应性可能是猫大颗粒淋巴瘤组织学诊断的有用标志物。
