Kabir Y, Kimura S
Department of Food Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Ann Nutr Metab. 1993;37(1):33-8. doi: 10.1159/000177746.
The biodistribution and metabolism of [8-14C]-octacosanol in rats were investigated to understand the mechanism of increased physical exercise and motor endurance by octacosanol. After 14C-octacosanol administered, radioactivity of octacosanol was mainly found in adipose tissue, especially in brown adipose tissue. Absorption of octacosanol is very low and mainly excreted through feces. The radioactivity of octacosanol was also partly expired as 14CO2. About 49% of the administered dose were excreted through different pathways. Metabolites of octacosanol are present in the urine. Octacosanol may be partly oxidized and degraded to fatty acids through beta-oxidation.
研究了[8-14C]-二十八烷醇在大鼠体内的生物分布和代谢，以了解二十八烷醇增强体育锻炼和运动耐力的机制。给予14C-二十八烷醇后，二十八烷醇的放射性主要存在于脂肪组织中，尤其是棕色脂肪组织。二十八烷醇的吸收非常低，主要通过粪便排出。二十八烷醇的放射性也有一部分以14CO2的形式呼出。约49%的给药剂量通过不同途径排出。二十八烷醇的代谢产物存在于尿液中。二十八烷醇可能通过β-氧化部分被氧化并降解为脂肪酸。
