Kabir Y, Kimura S
Department of Food Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Ann Nutr Metab. 1995;39(5):279-84. doi: 10.1159/000177873.
The present study investigates the metabolic disposition of octacosanol in liver and muscle of rats after serial doses administration. Three groups of experimental animals received various doses of (8-14C)-octacosanol (2.0 microCi/dose) orally through a stomach tube. When expressed per organ, the highest amount of radioactivity was found in the liver (9.5% of administered dose), followed by the digestive tracts (8.2%) and the muscle (3.5%) at all doses of administration. The radioactivity in all other tissues examined was insignificant (< 0.9% in each) at any time during this period. The radioactivity in liver disappeared rapidly after 2-dose administration, even when the doses were increased. In contrast, the muscle seemed to be able to store a considerable amount of octacosanol in response to doses of administration. In case of 9-dose serial administration, after 3 and 9 days the accumulation of radioactivity in muscle was higher than that of the liver, possibly due to slow elimination of radioactivity from muscle. By the time when radioactivity in liver and muscle was low (after 6 and 10 doses), the radioactivity of octacosanol in plasma reached a maximum, particularly after administration of 6 doses. The plasma concentration and the fecal excretion of the radioactivity of octacosanol reached a maximum at the third day after the oral 6 doses, which reflected not only the saturation of radioactivity uptake by liver and muscle but also the metabolism and excretion of octacosanol with time at the same period. The results are discussed in the light of the role of octacosanol in increasing muscle endurance in exercise.
本研究调查了连续给药后大鼠肝脏和肌肉中二十八烷醇的代谢分布情况。三组实验动物通过胃管口服给予不同剂量的（8-¹⁴C）-二十八烷醇（2.0微居里/剂量）。按器官计算，在所有给药剂量下，肝脏中放射性含量最高（占给药剂量的9.5%），其次是消化道（8.2%）和肌肉（3.5%）。在此期间的任何时候，所有其他检测组织中的放射性均不显著（各组织中均<0.9%）。两次给药后，肝脏中的放射性迅速消失，即使增加剂量也是如此。相比之下，肌肉似乎能够在给药后储存相当数量的二十八烷醇。在连续给药9次的情况下，给药3天和9天后，肌肉中放射性的积累高于肝脏，这可能是由于肌肉中放射性消除缓慢所致。当肝脏和肌肉中的放射性较低时（6次和10次给药后），血浆中二十八烷醇的放射性达到最大值，尤其是在给药6次后。口服6次给药后第三天，二十八烷醇放射性的血浆浓度和粪便排泄量达到最大值，这不仅反映了肝脏和肌肉对放射性摄取的饱和，也反映了同一时期二十八烷醇随时间的代谢和排泄情况。根据二十八烷醇在提高运动中肌肉耐力方面的作用对结果进行了讨论。
